Journal: Cancer Informatics
Article Title: Comparative RNA-Seq Analysis of Colon Spheroids and Patient-derived Tissues Identifies Non-Canonical Transcript Isoforms of Protein-Coding Genes Implicated in Colon Carcinogenesis
doi: 10.1177/11769351251396250
Figure Lengend Snippet: (A) Expression level of selected dysregulated transcripts NTMT1-204, BLOC1S6-218 and DCTN1-205 using patient data retrieved from UCSC Xena browser (n TCGA Tumor = 288, n TCGA Adjacent Non-Tumor Tissue = 41, n GTEx = 308). Data are presented as mean ± standard deviation (SD). **** P < .0001, n-number of samples. (B) Expression level of NTMT1-204 across colorectal cancer stages I-IV using patient data retrieved from UCSC Xena browser (n Stage I = 44, n Stage II = 109, n Stage III = 80, n Stage IV = 40). ** P < .01, n-number of samples. Data are derived from TCGA bulk RNA-seq, and observed expression patterns may be influenced by tumor purity and the presence of non-epithelial cell populations.
Article Snippet: High-throughput next generation RNA sequencing was performed by Novogene (UK) Company Limited (Cambridge, United Kingdom).
Techniques: Expressing, Standard Deviation, Derivative Assay, RNA Sequencing